The player may choose from a range of preset difficulty levels, affecting how challenging Missions are and the rewards obtained from them.
Some Difficulty levels are not available at the start of the game, and will unlock over time as the player performs well on Missions. Players can unlock up to 2 higher Difficulty levels from their current setting by receiving a 3 star rating on 3 Missions, or by receiving a 2 star rating a larger number of times.
| Difficulty | Description | Enemy Health | Enemy Offense | Revives | Combat Injuries | Enemy Reinforcements | Hero XP Bonus | Gloss Bonus |
|---|---|---|---|---|---|---|---|---|
| Story | For those who want to take in the story of the Midnight Suns and operate with impunity in combat. | -25% | -33% | Infinite | Disabled | Normal | +0% | +0% |
| Normal | The starting point for players new to Midnight Suns. | +0% | +0% | 2 | Enabled | Normal | +0% | +25% |
| Heroic I | Increased challenge and reward in combat. | +25% | +12.5% | 1 | Enabled | Normal | +10% | +50% |
| Heroic II | Increased challenge and reward in combat. | +50% | +25% | 1 | Enabled | Normal | +20% | +75% |
| Heroic III | Increased challenge and reward in combat. | +75% | +67% | 1 | Enabled | Normal | +25% | +100% |
| Ultimate I | A serious challenge intended for serious players. | +87.5% | +67% | 1 | Enabled | Additional | +30% | +125% |
| Ultimate II | A serious challenge intended for serious players. | +100% | +82% | 1 | Enabled | Additional | +35% | +150% |
| Ultimate III | An extreme challenge intended for tactical masterminds. | +125% | +100% | 0 | Enabled | Additional | +40% | +175% |